Welcome to IMIB
The Institute for Molecular Infection Biology (IMIB) is an interdisciplinary research institution of the Medical Faculty, University of Würzburg, with strong links to the Faculty of Biology. Members of the institute investigate fundamental biological problems and molecular mechanisms, with a focus on pathogens and infectious disease processes. IMIB research involves studies of bacteria, parasites and fungi, as well as their eukaryotic host, and ranges from bacterial and eukaryotic cell biology and immunology to fundamental aspects of gene regulation and RNA biology. Furthermore, the institute is home to the four groups of the prestigious ZINF Young Investigator program of the interfaculty Research Center for Infectious Disease Research (ZINF) in Würzburg. Our scientists lecture university seminars and practical courses to biology, medical and dental students. Education of graduate students is valued at IMIB, and the institute is an active member of the international Graduate School of Life Sciences (GSLS) of the university. Following the successful start of IMIB in 1993 with Prof. Jörg Hacker as the founding director, Prof. Jörg Vogel has been chair of the institute since 2009.
Drug-induced mating competence enables C. albicans cells to combine individually aquired resistance mechanisms News
The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal drug fluconazole by various mechanisms, with clinically relevant high resistance levels requiring a combination of these mechanisms. Joachim Morschhäuser’s group from IMIB now report in mBio that under selective pressure by the drug, those cells in a population that have acquired resistance mutations undergo genetic recombination events that further increase drug resistance and simultaneously make this normally asexual fungus mating-competent. Mating of resistant cells and subsequent reassortment of their combined chromosome sets generates progeny that is highly drug-resistant. (read more)